Genetic differences must be accounted for in studies of smoking risk of renal cell cancer. Innate risk of cancer varies with the ability to metabolise environmental toxins, some of which may be carcinogenic.
Evidence from:
JC Semenza et al. American Journal of Epidemiology. May (2001) Vol. 153 #9. p 851.
In this study there were clear differences of rsik between those with a high capacity to acetylate toxins and those with an impaired capacity, regardless of smoking history. Innate vulnerability is not a defence but may be used to discover and bolster causation arguments.
The Radar report is available to subscribers: